At high-pT hadron colliders, the search for new phenomena in final state leptons is one of the most promising ways to probe for TeV scale BSM physics affecting semi-leptonic transitions. In this talk I discuss how current LHC searches in neutral and charged Drell-Yan production can produce competetive limits on generic BSM models that complement those coming from low-energy flavor physics. In particular, we describe how high-pT searches could ultimately discover, or rule out, some of the most promising UV models that explain the apparent violation of lepton flavor universality in B decays.