The Drell-Yan processes pp->ll and pp->l nu at high transverse momentum can provide important probes of semileptonic transitions that are complementary to low-energy flavor physics observables. We derive constraints on the New Physics contributions to these processes by recasting the latest ATLAS and CMS searches for mono- and di-lepton resonances. We then study the interplay between low-energy observables and collider constraints, within the unified framework introduced with the "HighPT" package. Moreover, we investigate the validity limit of the Standard Model Effective Field Theory (SMEFT) in these regimes by comparing the limits obtained for specific explicit tree-level mediators and their EFT equivalent.