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SUMMARY:[DBS seminar] Andraž Stožer & Marko Gosak\, "From Ca²⁺ Waves 
 to Insulin Pulses: Experimental and Theoretical Perspectives on β-Cell Ne
 twork Dynamics"
DTSTART:20260514T121500Z
DTEND:20260514T131500Z
DTSTAMP:20260508T024500Z
UID:indico-event-3643@indico.ijs.si
CONTACT:anze.bozic@ijs.si
DESCRIPTION:Pancreatic β-cells within the islets of Langerhans coordinate
  their activity to generate pulsatile insulin secretion\, a process essent
 ial for glucose homeostasis and disrupted during the development of diabet
 es. This seminar will combine experimental physiology and mathematical mod
 elling to examine how multicellular β-cell networks encode\, propagate\, 
 and translate Ca²⁺ signals into insulin release. In the experimental pa
 rt\, we will present insights from high-frequency confocal Ca²⁺ imaging
 \, showing how β-cells respond heterogeneously to stimulation\, how fast 
 Ca²⁺ oscillations and intercellular waves emerge within islets\, and ho
 w specific cellular subpopulations may contribute to signal initiation and
  propagation. We will also discuss conserved and altered features of these
  dynamics in human islets and during diabetes progression. Building on the
 se findings\, the modelling part will address why mathematical abstraction
  is needed to disentangle the mechanisms underlying such complex multiscal
 e behaviour. We will present a phenomenological multicellular model that l
 inks structural gap-junction coupling\, timescale-specific functional conn
 ectivity\, and secretion. The model reproduces experimentally observed slo
 w metabolic oscillations\, fast bursts\, and ultrafast spikes\, and shows 
 how interactions between these temporal domains shape pulsatile insulin ou
 tput. By integrating high-resolution Ca²⁺ imaging with phenomenological
  modelling\, the seminar highlights how interdisciplinary approaches can r
 eveal the principles governing β-cell network function and its disruption
  in diabetes.\n\n\nhttps://indico.ijs.si/event/3643/
LOCATION:Seminar room of physics (106) (IJS)
URL:https://indico.ijs.si/event/3643/
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